Which WBC is capable of further differentiation in tissues?

Which WBC is capable of further differentiation in tissues?

• A. Neutrophil
• B. Eosinophil
• C. Basophil
• D. Monocyte

Answer: (D)

Monocytes are circulating precursors that migrate into tissues, where they differentiate into macrophages or dendritic cells. In tissues, these cells become specialized antigen-presenting or phagocytic cells, driven by local signals and cytokines such as M-CSF. Neutrophils, eosinophils, and basophils finish maturation in the bone marrow and, once in tissues, perform their effector roles without further differentiation. Macrophages and dendritic cells arising from monocytes are the key examples of WBCs that undergo further differentiation in tissues, enabling sustained innate and adaptive immune responses.

Monocytes are circulating precursors that migrate into tissues, where they differentiate into macrophages or dendritic cells. In tissues, these cells become specialized antigen-presenting or phagocytic cells, driven by local signals and cytokines such as M-CSF. Neutrophils, eosinophils, and basophils finish maturation in the bone marrow and, once in tissues, perform their effector roles without further differentiation. Macrophages and dendritic cells arising from monocytes are the key examples of WBCs that undergo further differentiation in tissues, enabling sustained innate and adaptive immune responses.